Sega Mega Drive
While it isn't the best video game ever, it is probably the best known werewolf game. But wait! It's also the best known weretiger game, the best known werebear game, and the best known wereDRAGON game. All they forgot were wereskunks. As the hero, you wise fwom yow gwave, and beat up monsters and zombies. As you do, you collect blue orb thingies that make you into a weremonster, then you fight an evil wizard to save your girlfriend. Well isn't that nice?