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#OKILAB te muestra: Con esta imagen ya no se te olvidará el mecanismo de defensa de la fagocitosis. Phagocytosis. The figure shows ingestion‚ digestion‚ and destruction of foreign particulate matter (a bacterium‚ in this example)

The figure shows ingestion‚ digestion‚ and destruction of foreign particulate matter (a bacterium‚ in this example).

nivolumab mechanism of action in cancer treatment. Checkpoint inhibitors are known to cause immune related adverse events, trigger autoimmunity

this is otherwise known as this is a monoclonal antibody used to treat to suppress expression of which will allow for t cell production and increased effector function.

terleukins The name (IL) followed by a number (for example IL-l or IL-2) was coined in an attempt to develop a standardized nomenclature for molecules secreted by, and acting on, leukocytes.  IL-1: It is an acute phase reactant synthesized by macrophages contributing to the acute inflammatory response, including fever, leukocyte recruitment, adhesion molecule activation, and stimulation of further chemokine production.  Mnemonic: One makes you burn like the sun. Immense Immunology Insight…

is one of the many pro-inflammatory cytokines that we learned about in class this week.

B cell Development and Activation

B cell Development and Activation - there is a bigger picture after visiting the website

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Direct and indirect activation of NK cells. The “classical” pathway of NK cell activation (A,B) results from skewing of the balance between signals transmitted via inhibitory and activating receptors. The “indirect” pathway of NK cell activation results from contact-dependent and soluble signals derived from accessory cells and T cells transmitted to activating receptors on NK cells (C).

Direct and indirect activation of NK cells. The “classical” pathway of NK cell activation (A,B) results from skewing of the balance between signals transmitted via inhibitory and activating receptors. The “indirect” pathway of NK cell activation results from contact-dependent and soluble signals derived from accessory cells and T cells transmitted to activating receptors on NK cells (C).

The T cell antigen receptor: the Swiss army knife of the immune system http://onlinelibrary.wiley.com/enhanced/doi/10.1111/cei.12622/?utm_content=buffer016fd&utm_medium=social&utm_source=pinterest.com&utm_campaign=buffer #immunology #openaccess #journal #science

The T cell antigen receptor: the Swiss army knife of the immune system

Antigen-specific effector memory CD4+ T cells recruit NK cells as effector cells in adaptive immune responses. During 1ª infection, NK cells receive innate ++ signals from myeloid accessory cells and make very limited responses (left). Upon re-exposure to a pathogen, Ag-specific CD4+ T cells produce IL-2. Accessory cell together with this IL-2, induce an “adaptive” NK cell responses, including NK cell proliferation, secretion of effector molecules, and killing of affected target cells…

Antigen-specific effector memory CD4+ T cells recruit NK cells as effector cells in adaptive immune responses. During 1ª infection, NK cells receive innate ++ signals from myeloid accessory cells and make very limited responses (left). Upon re-exposure to a pathogen, Ag-specific CD4+ T cells produce IL-2. Accessory cell together with this IL-2, induce an “adaptive” NK cell responses, including NK cell proliferation, secretion of effector molecules, and killing of affected target cells…

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