Quatro began her musical career at the age of fourteen. She played the bass guitar in the all-female bands The Pleasure Seekers and Cradle with her sisters Patti, Nancy, and Arlene. Also, according to her autobiography, her first bass guitar was a 1957 Fender Precision, given to her by her father. Patti Quatro later joined the band Fanny, one of the earliest all-female rock bands to gain national attention. She has a brother, Michael Quatro, who is also a musician.